CALL FOR PAPERS Sex and Gender Differences in Renal Physiology Sex-dependent expression of water channel AQP1 along the rat nephron
نویسندگان
چکیده
Carol M. Herak-Kramberger, Davorka Breljak, Marija Ljubojević, Mirela Matokanović, Mila Lovrić, Dunja Rogić, Hrvoje Brzica, Ivana Vrhovac, Dean Karaica, Vedran Micek, Jana Ivković Dupor, Dennis Brown, and Ivan Sabolić Molecular Toxicology, Institute for Medical Research and Occupational Health, Zagreb, Croatia; Clinical Institute of Laboratory Diagnosis, University Hospital Center, Zagreb, Croatia; Department of Biotechnology, University of Rijeka, Rijeka, Croatia; Program in Membrane Biology and Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
منابع مشابه
Sex-dependent expression of water channel AQP1 along the rat nephron.
In the mammalian kidney, nonglycosylated and glycosylated forms of aquaporin protein 1 (AQP1) coexist in the luminal and basolateral plasma membranes of proximal tubule and descending thin limb. Factors that influence AQP1 expression in (patho)physiological conditions are poorly known. Thus far, only angiotensin II and hypertonicity were found to upregulate AQP1 expression in rat proximal tubul...
متن کاملMixed descending- and ascending-type thin limbs of Henle's loop in mammalian renal inner medulla.
Previous studies have generally indicated that the entire descending (DTL) and ascending thin limbs (ATL) of Henle's loops in the mammalian inner medulla exhibit structurally and functionally distinct properties. In the present study, we found that about 50% of Munich-Wistar rat inner medullary thin limbs, lying at positions distinctly above the bend, had segments exhibiting structural characte...
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Cyclophosphamide is clinically useful in treating malignancy and rheumatologic disease, but has limitations in that it induces hyponatremia. The mechanisms by which cyclophosphamide induces water retention in the kidney have yet to be identified. This study was undertaken to test the hypothesis that cyclophosphamide may produce water retention via the proximal nephron, where aquaporin-1 (AQP1) ...
متن کاملRat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition.
In rats, the secretion of p-aminohippurate (PAH) by the kidney is higher in males (M) than in females (F). The role of the major renal PAH transporters, OAT1 and OAT3, in the generation of these gender differences, as well as the responsible hormones and mechanisms, has not been clarified. Here we used various immunocytochemical methods to study effects of gender, gonadectomy, and treatment wit...
متن کاملSex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys.
In the mouse kidney, organic anion transporter 3 (mOat3, Slc22a8) was previously localized to the basolateral membrane (BLM) of proximal tubule (PT), thick ascending limb of Henle, macula densa, distal tubule, and cortical collecting duct. However, the specificity of anti-Oat3 antibodies (Oat3-Ab) used in these studies was not properly verified. Moreover, the sex-dependent expression of mOat3, ...
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